Projects

PROJECTS

As a team we have wide ranging experience from small academic studies to large multi-national clinical trials. A selection of some recent projects have been detailed below.

CAPRICORN
(Carvedilol Post Infarction Survival Control in Left Ventricular Dysfunction)
ROSIGLITAZONE HEART FAILURE TRIAL
ENABLE
(Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure).
ASCEND-HF
(Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure)
SCOT
(The Standard care versus Celecoxib Outcome Trial): Safety study designed to compare the cardiovascular safety of celecoxib versus traditional non-selective non steroidal anti-inflammatory drug therapy.
FAST
(Febuxostat versus Allopurinol Streamlined Trial): Long term cardiovascular safety of febuxostat in comparison with allopurinol in patients with chronic symptomatic hyperuricaemia.
ASP1941
Clinical development of ASP1941 in the treatment of type 2 diabetes mellitus (cardiovascular safety)
Harmony Programme
(analysis of cardiovascular safety of albiglutide)
KODIAC Phase 111 Programme
(cardiovascular safety of naloxegol in opioid induced constipation)
TRUE-AHF
(Phase 111, Multicenter, Randomised, Double-Blind, Placebo –Controlled Trial to Evaluate the Efficacy and Safety of Ularitide (Urodilatin) Intravenous Infusion in Patients Suffering from Acute Decompensated Heart Failure)
PIVOTAL
(Proactive IV irOn Therapy in haemodiALysis patients) trial.
BETonMACE
A Phase III multi-center, double-blind, randomized, parallel group, placebo-controlled clinical trial in high-risk type 2 diabetes mellitus subjects with coronary artery disease to determine whether treatment with RVX000222 increases the time to major adverse cardiovascular events.)

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